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Welcome to the Butler Group page at University College Dublin.

dna_botanisThe lab is interested in studying factors controlling virulence in pathogenic fungi, and in particular we are identifying the regulatory pathways controlling the growth of biofilms of Candida parapsilosis on medical devices; investigating the response of pathogenic yeast to hypoxia; and characterising the role of specific yeast transcription factors in virulence in animal models. We have developed  methods for generating gene knockouts in Candida parapsilosis, including the application of CRISPR, and we are currently constructing a set of individual knockouts.We use a number of comparative genomics approaches to study  evolution of the Candida clade, including genomic sequencing and RNA-seq. We developed a genome browser (the Candida Gene Order Browser) to enable analysis of Candida genomes.

The lab is a participant in the OPATHY International Training Network, “From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts”.

Follow the links at the top to people, publications etc.

Butler biography at UCD is available here.

(DNA sculpture in Botanic Gardens, Dublin)

 

Tools

The Candida Gene Order Browser: http://cgob.ucd.ie

Contact

Prof Geraldine Butler, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

Email: gbutler@ucd.ie  Phone: +353-1-7166885

Biology Big Data at The Conway Institute